Ramachandrasastri Marepalli was a poet and a pundit in English, Sanskrit and Telugu languages. He was able to perform "ashtaavadhaana". He founded several schools including Ayurveda schools, Vedic schools, girls' schools, night schools etc. He established "kalaabhilaasha kaavyamaala" and published several books. He also established libraries and participated in library movement. He was one of the editors of "grandhaalaya sarvasva patrika." His works include poetry, prose, stories, Harikathas (Stories of the Supreme Being), essays etc. He recognized the importance of informal language (vaadukabhaasha).

He was a social reformer also. He worked to eradicate child marriages, encouraged widow marriages, attempted rehabilitation of prostitutes, encouraged downtrodden by establishing schools for them, tried to eradicate segregation, established hospitals etc. He also encouraged handicrafts and craftsmen by providing support.  He recognized the destruction of native religions due to Christian missionaries and tried to protect the endangered native religions. For that purpose, he established Haindava-hita-sabha and began Sri Ramanavami celebrations to reinvigorate the native religions.

He was also a freedom fighter.  He joined Andhra mahaasabha and worked for a separate state of Andhra from Madras province. He founded "swaraajya samiti", participated in freedom movement of India, gave lectures in every village in Andhra, participated in uppu satyaagraha (salt civil disobedience) and went to jail. He was one of the eminent Andhra leaders of that era.